Request Sample

Products

Products

WhatsApp

+86 18626059817

Email

cora@wxqysteel.com

Address

Shandong Province

Curcumin CAS#458-37-7

  • Curcumin CAS#458-37-7
  • Curcumin CAS#458-37-7
  • Curcumin CAS#458-37-7
  • Curcumin CAS#458-37-7
  • Curcumin CAS#458-37-7

Curcumin CAS#458-37-7

Powerful Antioxidant：Curcumin prevents oxidative stress by inhibiting nitric oxide (NO) production and reducing markers of oxidative damage, such as 3-nitrotyrosine (3-NT).


Strong Anti-Inflammatory Activity：It suppresses the release of histamine and inflammatory cytokines (TNF-α, IL-1β, IL-6, IL-8), reducing inflammation in both cellular and animal models.


Antitumor Effects：Curcumin decreases tumor formation in mouse skin and reduces the number of preneoplastic lesions and neoplasms in animal models.


Protective in Allergic and Cardiovascular Conditions：It mitigates histopathological changes in nasal mucosa, reduces symptoms of rhinitis, and shows protective effects against cardiovascular oxidative stress.



Phone ：+86 18626059817
WhatsApp ：+86 18626059817
Email ：cora@wxqysteel.com
product description

Product Description of Curcumin CAS#458-37-7

Curcumin is the primary yellow pigment found in turmeric and curry, known for its antioxidant, anti-inflammatory, and antitumor properties. It effectively inhibits nitric oxide (NO) production (IC50 = 6 μM) and reduces inducible nitric oxide synthase (iNOS) activity in LPS-stimulated RAW 264.7 cells. Curcumin also suppresses the release of histamine and inflammatory cytokines, including TNF-α, IL-1β, IL-6, and IL-8, from HMC-1 mast cells.

In vivo studies show that curcumin lowers serum levels of histamine and TNF-α, prevents histopathological changes in the nasal mucosa, and reduces sneezing and nasal rubbing in a mouse model of ovalbumin-induced rhinitis. Additionally, curcumin (100 or 200 mg/kg) inhibits the accumulation of 3-nitrotyrosine (3-NT), a marker of oxidative stress, in the hearts of mice. Topical application (1–10 μmol) decreases the number of tumors induced by phorbol 12-myristate 13-acetate (TPA) in mouse skin, while dietary administration reduces tongue neoplasms and preneoplastic lesions caused by 4-nitroquinoline 1-oxide (4-NQO) in rats.


Product Application of Curcumin CAS#458-37-7

Curcumin is a natural phenolic compound with potent anti-tumor, anti-inflammatory, and antioxidant properties. It induces apoptosis in cancer cells and inhibits phorbol ester-induced protein kinase C (PKC) activity. Curcumin has been reported to suppress the production of inflammatory cytokines by peripheral blood monocytes and alveolar macrophages. It is a strong inhibitor of EGFR tyrosine kinase and IκB kinase, and also inhibits inducible nitric oxide synthase (iNOS), cyclooxygenase, and lipoxygenase.

Curcumin readily penetrates the cytoplasm of cells, accumulating in membranous structures such as the plasma membrane, endoplasmic reticulum, and nuclear envelope, enhancing its biological activity.


Product Information

Parameters


Melting point183 °C
Boiling point418.73°C (rough estimate)
Density0.93
Vapor density13 (vs air)
Refractive index1.4155-1.4175
Fp208.9±23.6 °C
Storage temp2-8°C
Solubilityethanol: 10 mg/mL
Pka8.09(at 25℃)
Formpowder
Colour Index75300
Colororange
OdorOdorless
PH RangeYellow (7.8) to red-brown (9.2)
biological sourceCurcuma longa (Turmeric)
Water SolubilitySlightly soluble (hot)
λmax430nm
Merck142673
BRN2306965
Concentration1 mCi/ml
SolventEthanol
Specific Activity5-15 Ci/mmol
StabilityStable, but may be light sensitive. Incompatible with strong oxidizing agents.
Major ApplicationCosmetics, drug-eluting stents, inhibition of formation of skin-wrinkles, treating alzheimer’s disease, skin diseases, coronary restenosis, diabetes, obesity, leukemia, neurofibromas, cancer, antimicrobial, antiviral, antiinflammatory, antiprostate cancer
InChIKeyVFLDPWHFBUODDF-FCXRPNKRSA-N
LogP3.290 (est)
CAS DataBase Reference458-37-7(CAS DataBase Reference)
EPA Substance Registry SystemCurcumin (458-37-7)


Safety Information


Hazard CodesXi
Risk Statements36/37/38
Safety Statements26
WGK Germany3
RTECSMI5230000
Hazard NoteIrritant
TSCAYes
HS Code29145000
Hazardous Substances Data458-37-7(Hazardous Substances Data)
ToxicityLD50 Oral-Rat-12.200 mg/kg


Factory Showcase
拼图_美图设计室-(1)
Quality Control Lab
未标题-2
Shipping And Transportation
拼图_美图设计室
FAQ
Q：

Are you a manufacturer or a trader?

A：
We are a supply chain service provider rather than a single manufacturer. Instead of being tied to one specific factory, we have established deep partnerships with numerous high-quality domestic chemical enterprises that hold certifications such as ISO and REACH. This allows us to flexibly match the most suitable supply sources to your needs while independently conducting third-party quality inspections to ensure delivery quality and price competitiveness.
Q：

How do your overseas warehouses operate, and what are the practical benefits?

A：
We maintain transit warehouses with standing inventory in Southeast Asia, the Middle East, and Eastern Europe.
For you: You can pick up goods directly from local warehouses without the need for full-container orders; delivery times are reduced from the standard 30–45 days to just 3–5 days.
Reduced inventory pressure: You can purchase small batches for trial and quality verification before scaling up orders, avoiding the need to tie up large amounts of capital upfront.
Emergency restocking: If your production line faces a sudden material shortage, we can urgently dispatch supplies from our regional warehouses to prevent production downtime.
Q：

What is the Minimum Order Quantity (MOQ)?

A：
For standard products, the MOQ is typically one 20-foot container (approx. 16–20 tons) for direct shipments from China. However, for stock picked up from overseas warehouses, we support orders starting from 1 ton—ideal for sample testing or small-batch production. Specific MOQs depend on the product category and packaging type; please contact us for details.
Q：

How do you ensure product quality?

A：
We implement a "three-level quality control" system:
Before leaving the factory: We require the factory to provide a Certificate of Analysis (COA) for the specific batch.
Before shipment: We commission international third-party agencies like SGS or Intertek to conduct random inspections, with costs covered by us (for long-term partners).
After arrival: If quality issues arise, we commit to unconditional negotiation regarding returns, exchanges, or compensation, and we assume full responsibility. All terms are stipulated in the contract.
Q：

What payment methods do you accept? Do you offer credit terms?

A：
We accept T/T (Telegraphic Transfer), L/C (Letter of Credit at sight or usance), and D/P (Documents against Payment). For clients with a long-standing partnership and good credit standing, we offer partial credit terms (e.g., 30–60 days), subject to negotiation based on transaction history and due diligence results. Cash on Delivery (COD) is available for local customers ordering in-stock items from our overseas warehouses.
Q：

What is the typical delivery lead time?

A：
FOB (China Port): Goods are prepared and shipped within 7–15 working days after the contract is signed and the prepayment is received.
Overseas Warehouse Stock: Items are dispatched within 1–3 working days of order confirmation and payment; local delivery typically takes 2–5 days (depending on the country).
Q：

Which trade terms do you offer? Do you support DDP (Delivered Duty Paid)?

A：
We are proficient in handling common terms such as FOB, CIF, CFR, and EXW. Additionally, for regions covered by our overseas warehouses, we offer DDP services (including duties and door-to-door delivery), allowing you to receive goods without the hassle of complex import customs clearance procedures. Please consult your sales manager for specific costs.
Q：

How can I obtain samples? What are the costs?

A：
If stock is available at an overseas warehouse, we can provide 1–2 kg of samples for free; you only need to cover the local courier fees.
If shipping from China, we can arrange delivery via DHL or FedEx; samples are free, but you bear the international shipping costs. Once a clear intent to cooperate is established, these shipping costs can be deducted from your first order.
Q：

Can the contract price be adjusted if product prices fluctuate?

A：
We offer a price protection mechanism:
For fixed-price contracts, we do not unilaterally raise prices due to market increases.
If you anticipate a market downturn, we can negotiate floating pricing—settling based on a benchmark price on the date of shipment or arrival—to flexibly manage fluctuations.
Q：

What does your after-sales service include?

A：
We provide full-lifecycle service:
Usage Guidance: Assistance with adjusting processing parameters (if required).
Complaint Handling: Response within 48 hours and a solution provided within 7 days.
Regular follow-ups: Proactive contact every six months to understand changing needs and optimize supply solutions.
Contact Us
Submit
Recommendation
Inquiry