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Ketoconazole CAS#65277-42-1

  • Ketoconazole CAS#65277-42-1
  • Ketoconazole CAS#65277-42-1
  • Ketoconazole CAS#65277-42-1
  • Ketoconazole CAS#65277-42-1
  • Ketoconazole CAS#65277-42-1

Ketoconazole CAS#65277-42-1

Broad-Spectrum Antifungal Activity：Ketoconazole is an imidazole antifungal effective against a wide range of fungal infections, including superficial and deep mycoses.


Selective Inhibition of Ergosterol Biosynthesis：It blocks ergosterol synthesis by interfering with fungal cytochrome P-450, disrupting cell membranes and preventing fungal growth.


Prevention of Fungal Growth and Spore Transformation：Ketoconazole inhibits fungal growth and prevents spores from forming mycelium, reducing reinfection risk.


Antibacterial and Clinical Versatility：It acts against Candida, Coccidioides, Histoplasma, Sporothrix, and Trichophyton, and is used to treat tinea pedis, tinea corporis, tinea cruris, thrush, and skin candidiasis.



Phone ：+86 18626059817
WhatsApp ：+86 18626059817
Email ：cora@wxqysteel.com
product description

Product Description of Ketoconazole CAS#65277-42-1

Ketoconazole is a broad-spectrum imidazole antifungal agent. It inhibits fungal cytochrome P450 to block ergosterol synthesis and damage fungal cell membranes. It suppresses fungal proliferation and spore development, exerting bacteriostatic and bactericidal effects. Effective against various fungi, it is widely used for treating multiple superficial and systemic fungal skin and mucosal infections.


Product Application of Ketoconazole CAS#65277-42-1

Ketoconazole is a broad-spectrum imidazole antifungal for various fungal infections including tinea pedis, candidiasis and systemic mycoses. As a CYP3A4 inhibitor, it is also widely used in pharmacological research for bioavailability assessment, antitumor study and drug interaction analysis.

Product Information

Parameters


Melting point148-152 °C
Boiling point753.4±60.0 °C(Predicted)
density1.4046 (rough estimate)
refractive index-10.5 ° (C=0.4, CHCl3)
Fp9℃
storage temp.2-8°C
solubilitymethanol: soluble50mg/mL
pkapKa 3.25/6.22(H2O,t =25,I=0.025) (Uncertain)
formOff-white solid
colorwhite to light yellow
optical activity[α]20/D -1 to 1°, c = 4 in methanol
Water SolubilitySoluble in DMSO, ethanol, chloroform, water, and methanol.
Merck145302
BCS Class2
Stability:Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
InChIKeyXMAYWYJOQHXEEK-OZXSUGGESA-N
LogP4.35
CAS DataBase Reference65277-42-1(CAS DataBase Reference)


Safety Information


Hazard CodesT,N,F
Risk Statements25-36/37/38-23/24/25-50/53-48/22-60-39/23/24/25-11
Safety Statements36-45-36/37/39-26-61-60-53-36/37-16-7
RIDADRUN 2811 6.1/PG 3
WGK Germany3
RTECSTK7912300
HazardClass6.1(b)
PackingGroupIII
HS Code29349990
Hazardous Substances Data65277-42-1(Hazardous Substances Data)
ToxicityLD50 in mice, rats, guinea pigs, dogs (mg/kg): 44, 86, 28, 49 i.v.; 702, 227, 202, 780 orally (Heel)


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We are a supply chain service provider rather than a single manufacturer. Instead of being tied to one specific factory, we have established deep partnerships with numerous high-quality domestic chemical enterprises that hold certifications such as ISO and REACH. This allows us to flexibly match the most suitable supply sources to your needs while independently conducting third-party quality inspections to ensure delivery quality and price competitiveness.
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We maintain transit warehouses with standing inventory in Southeast Asia, the Middle East, and Eastern Europe.
For you: You can pick up goods directly from local warehouses without the need for full-container orders; delivery times are reduced from the standard 30–45 days to just 3–5 days.
Reduced inventory pressure: You can purchase small batches for trial and quality verification before scaling up orders, avoiding the need to tie up large amounts of capital upfront.
Emergency restocking: If your production line faces a sudden material shortage, we can urgently dispatch supplies from our regional warehouses to prevent production downtime.
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For standard products, the MOQ is typically one 20-foot container (approx. 16–20 tons) for direct shipments from China. However, for stock picked up from overseas warehouses, we support orders starting from 1 ton—ideal for sample testing or small-batch production. Specific MOQs depend on the product category and packaging type; please contact us for details.
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We implement a "three-level quality control" system:
Before leaving the factory: We require the factory to provide a Certificate of Analysis (COA) for the specific batch.
Before shipment: We commission international third-party agencies like SGS or Intertek to conduct random inspections, with costs covered by us (for long-term partners).
After arrival: If quality issues arise, we commit to unconditional negotiation regarding returns, exchanges, or compensation, and we assume full responsibility. All terms are stipulated in the contract.
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FOB (China Port): Goods are prepared and shipped within 7–15 working days after the contract is signed and the prepayment is received.
Overseas Warehouse Stock: Items are dispatched within 1–3 working days of order confirmation and payment; local delivery typically takes 2–5 days (depending on the country).
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Which trade terms do you offer? Do you support DDP (Delivered Duty Paid)?

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We are proficient in handling common terms such as FOB, CIF, CFR, and EXW. Additionally, for regions covered by our overseas warehouses, we offer DDP services (including duties and door-to-door delivery), allowing you to receive goods without the hassle of complex import customs clearance procedures. Please consult your sales manager for specific costs.
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How can I obtain samples? What are the costs?

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If stock is available at an overseas warehouse, we can provide 1–2 kg of samples for free; you only need to cover the local courier fees.
If shipping from China, we can arrange delivery via DHL or FedEx; samples are free, but you bear the international shipping costs. Once a clear intent to cooperate is established, these shipping costs can be deducted from your first order.
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We offer a price protection mechanism:
For fixed-price contracts, we do not unilaterally raise prices due to market increases.
If you anticipate a market downturn, we can negotiate floating pricing—settling based on a benchmark price on the date of shipment or arrival—to flexibly manage fluctuations.
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We provide full-lifecycle service:
Usage Guidance: Assistance with adjusting processing parameters (if required).
Complaint Handling: Response within 48 hours and a solution provided within 7 days.
Regular follow-ups: Proactive contact every six months to understand changing needs and optimize supply solutions.
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