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Arbutin CAS#497-76-7

  • Arbutin CAS#497-76-7
  • Arbutin CAS#497-76-7
  • Arbutin CAS#497-76-7
  • Arbutin CAS#497-76-7
  • Arbutin CAS#497-76-7

Arbutin CAS#497-76-7

Potent Tyrosinase Inhibitor：Arbutin effectively inhibits human tyrosinase activity in melanocytes, helping reduce melanin formation and treat hyperpigmentation.


Strong Antioxidant Protection：It protects cells from free radical–induced damage, preventing hemolysis and improving skin fibroblast viability.


Powerful Anti-Inflammatory Activity：Arbutin suppresses inflammatory cytokines (IL-1β, IL-6, TNF-α) in vivo, demonstrating significant anti-inflammatory effects.


Effective Skin Brightening and Depigmenting Agent：Widely used in formulations for hyperpigmentation disorders, supporting skin whitening and tone-evening applications.


Phone ：+86 18626059817
WhatsApp ：+86 18626059817
Email ：cora@wxqysteel.com
product description

Product Description of Arbutin CAS#497-76-7

Arbutin is a glycosylated form of hydroquinone naturally found in Arctostaphylos plants and exhibits a range of biological activities, including tyrosinase inhibition, antioxidant effects, and anti-inflammatory properties. It effectively suppresses human tyrosinase activity in crude enzyme preparations isolated from melanocytes (IC50 values of 5.7 and 18.9 mM using L-tyrosine and L-DOPA as substrates, respectively) as well as in intact melanocytes (IC50 = 0.5 mM).

At a concentration of 50 μM, arbutin inhibits hemolysis induced by the free radical generator AAPH in sheep erythrocytes, and at concentrations above 125 μM, it prevents AAPH-induced reductions in cell viability in cultured human skin fibroblasts. In an LPS-induced rat model of acute lung injury, arbutin (50 mg/kg) suppresses increases in IL-1β, IL-6, and TNF-α levels in both lung tissue and serum. Formulations containing arbutin have been widely applied in the treatment of hyperpigmentation disorders.


Product Application of Arbutin CAS#497-76-7

Arbutin is applied in diuretic and anti-infective medications for the urinary system. It is also used as a stabilizer in color photographic developing processes. In cosmetic formulations, arbutin is widely utilized for skin whitening, freckle reduction, and hair care applications.


Product Information

Parameters


Melting point195-198 °C
alpha-64 º (c=3)
Boiling point375.31°C (rough estimate)
density1.3582 (rough estimate)
refractive index-65.5 ° (C=4, H2O)
storage temp.Inert atmosphere,Room Temperature
solubilityH2O: 50 mg/mL hot, clear
formSolid
pka10.10±0.15(Predicted)
colorWhite
optical activity[α]/D -64.0±2.0°, c = 3 in H2O
biological sourcesynthetic or plant
Water Solubility10-15 g/100 mL at 20 ºC
SensitiveHygroscopic
Merck14773
BRN89673
Stability:Stable. Hygroscopic - store under dry nitrogen.
InChIKeyBJRNKVDFDLYUGJ-RMPHRYRLSA-N
LogP-1.35
CAS DataBase497-76-7(CAS DataBase Reference)
Reference
EPA Substance.beta.-D-Glucopyranoside, 4-hydroxyphenyl (497-76-7)



Safety Information


Hazard CodesXn
Risk Statements20/21/22-36/37/38
Safety Statements22-24/25-36-26
WGK Germany3
RTECSCE8863000
F37917
HS Code29389090
Hazardous497-76-7(Hazardous Substances Data)



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